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Some drugs used to treat high blood pressure, heart disease, arthritis, and psychiatric disorders can trigger psoriasis. ACE inhibitors, beta-blockers, and lithium are common offenders that can cause psoriasis flare-ups as well as malaria drugs, such as Plaquenil and hydroxychloroquine, and NSAIDs. Oral steroids such as prednisone work to control flares but may cause a worsening of the condition after coming off long-term use. Talk to your doctor if your medication is worsening your psoriasis.

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